Supplements & Nutraceuticals

The most studied sports supplement in history, now recognized for cognitive and longevity benefits beyond muscle performance. Safe, cheap, and effective.

The most important foundational supplement stack. Vitamin D3 is critical for immune function, bone health, and mood, while K2 directs calcium to bones and away from arteries.

The most universally recommended supplement in the longevity community. Critical for 300+ enzymatic reactions, sleep quality, muscle function, and nervous system regulation.

Essential fatty acids critical for brain health, cardiovascular function, and inflammation regulation. One of the most studied and recommended supplements globally.

An amino acid abundant in the heart, brain, and muscles that declines significantly with age. A landmark 2023 Science paper showed taurine deficiency is a driver of aging, and supplementation extended lifespan in mice by 10-12%. Now considered one of the most important longevity supplements.

A combination of glycine and N-acetylcysteine that replenishes glutathione — the body's master antioxidant. Baylor College clinical trials showed GlyNAC supplementation reversed multiple hallmarks of aging in older adults and extended lifespan 24% in mice.

An amino acid found primarily in green tea that promotes relaxation without sedation. Increases alpha brain waves, enhances focus when paired with caffeine, and improves sleep quality. Core component of Huberman's sleep protocol.

Comprehensive B vitamin supplementation including methylfolate (B9), methylcobalamin (B12), B6 (P5P), thiamine (B1), riboflavin (B2), niacin (B3), pantothenic acid (B5), and biotin (B7). Essential for energy production, methylation, neurological function, and homocysteine metabolism.

The most clinically validated adaptogen. Ashwagandha has strong evidence for reducing cortisol, improving stress tolerance, enhancing sleep quality, boosting testosterone, and supporting thyroid function. Used for over 3,000 years in Ayurvedic medicine.

An essential mitochondrial cofactor and potent antioxidant that declines with age. The landmark Q-SYMBIO trial demonstrated a 50% reduction in major cardiovascular events in heart failure patients. Widely used for energy, heart health, and statin side effect management.

A powerful glutathione precursor and mucolytic agent used clinically for liver protection, respiratory health, and as an antidote for acetaminophen toxicity. Widely adopted in the longevity community for its antioxidant, anti-inflammatory, and detoxification properties.

An NAD+ precursor vitamin (form of B3) that efficiently raises cellular NAD+ levels. More clinical trial data than NMN, with demonstrated benefits for cardiovascular health, brain function, and metabolic optimization. The basis for Tru Niagen, one of the best-selling longevity supplements.

Live beneficial bacteria (and their metabolic byproducts — postbiotics) that support gut microbiome health, immune function, mental health (gut-brain axis), and metabolic optimization. Strain-specific effects are critical — not all probiotics are the same.

Potent NRF2 pathway activator derived from cruciferous vegetables, especially broccoli sprouts. Upregulates the body's antioxidant defense system, supports detoxification, and has anti-cancer properties. One of the most researched natural compounds for cancer prevention and longevity.

A polyphenol found in red grapes and wine that activates SIRT1 longevity pathways. The Baur et al. 2006 Nature study sparked global interest, though poor oral bioavailability (~1%) limits human translation of the compelling animal data.

The premier nootropic mushroom, uniquely proven to stimulate Nerve Growth Factor (NGF) and Brain-Derived Neurotrophic Factor (BDNF) production. Research supports its use for cognitive enhancement, neuroprotection, and nerve regeneration.

Hydrolyzed collagen protein that supports skin elasticity, joint health, bone density, and gut lining integrity. Bryan Johnson takes 12.5g daily. The most abundant protein in the body, declining significantly after age 25.

An Arctic adaptogen with strong evidence for mental and physical fatigue reduction, stress resilience, and cognitive performance under pressure. Used by Viking warriors, Soviet athletes, and cosmonauts.

A direct precursor to NAD+, the critical coenzyme involved in cellular energy production and DNA repair. NMN supplementation raises NAD+ levels, supporting mitochondrial function, metabolic health, and healthy aging. Central to David Sinclair's longevity research and Bryan Johnson's Blueprint protocol.

A postbiotic metabolite that activates mitophagy — the selective recycling of damaged mitochondria. Originally derived from pomegranates and walnuts via gut bacteria, now available as a supplement (Mitopure). Strong clinical evidence for muscle strength and mitochondrial health in aging.

A bioactive alkaloid found in goldenseal, barberry, and Oregon grape with strong evidence for blood sugar control and cholesterol management. Often called 'nature's metformin' due to its AMPK-activating metabolic effects.

Key metabolic intermediate in the Krebs cycle that reduces inflammation, supports mitochondrial function, and extended lifespan 12% in mice. Bryan Johnson includes calcium-AKG in his stack.

A natural flavonoid found in chamomile, celery, and parsley. Part of Andrew Huberman's nightly sleep stack. Promotes sleep quality through mild anxiolytic effects and CD38 inhibition (preserving NAD+ levels).

Unique antioxidant that is both water and fat-soluble, allowing it to work throughout the body. Regenerates other antioxidants (vitamin C, E, glutathione), improves insulin sensitivity, supports nerve health, and aids in heavy metal chelation. R-form is the bioactive isomer.

A potent carotenoid antioxidant derived from microalgae. 6000x stronger than vitamin C as an antioxidant. Supports skin, eye, and cardiovascular health.

The nutrient-dense first milk produced after birth, rich in immunoglobulins, lactoferrin, growth factors, and antimicrobial peptides. Trending as a gut health and immune support supplement with growing clinical evidence for gut barrier repair and athletic recovery.

A Southeast Asian herb with strong clinical evidence for testosterone optimization, stress reduction, and body composition improvement. Andrew Huberman's primary recommendation for natural testosterone support.

Medicinal mushroom extracts used for cognitive enhancement (Lion's Mane), immune support (Reishi), energy (Cordyceps), and antioxidant protection (Chaga).

A natural senolytic combination that selectively clears senescent 'zombie' cells. Kirkland's Mayo Clinic research established quercetin as a senolytic, while Yousefzadeh showed fisetin extends lifespan ~10% in mice. First-in-human pilot data is promising.

Oral NAD+ precursors (NMN or NR) that boost cellular NAD+ levels. More accessible and affordable than injectable NAD+, though bioavailability is lower.

A natural polyamine found in wheat germ that activates autophagy — the body's cellular cleanup process. Emerging as a key longevity compound.

A mitochondrial electron carrier and monoamine oxidase inhibitor with cognitive-enhancing and neuroprotective properties. Used at micro-doses for brain health.