๐ŸŒฟ

Supplements & Nutraceuticals

Vitamins, minerals, botanical extracts, and nutraceutical compounds with clinical evidence for longevity, energy, cognition, and metabolic health.

13 treatmentsโ€ขAvg. score: 74/100
Creatine
90
๐Ÿ’ช

Creatine

Creatine Monohydrate

The most studied sports supplement in history, now recognized for cognitive and longevity benefits beyond muscle performance. Safe, cheap, and effective.

Strong700+ studiesโ€ข92% positive
MuscleCognitiveFoundational
Vitamin D3 + K2
88
โ˜€๏ธ

Vitamin D3 + K2

Vitamin D3 with Vitamin K2 (MK-7)

The most important foundational supplement stack. Vitamin D3 is critical for immune function, bone health, and mood, while K2 directs calcium to bones and away from arteries.

Strong300+ studiesโ€ข88% positive
Bone HealthImmuneFoundational
Omega-3
86
๐ŸŸ

Omega-3

Omega-3 Fatty Acids (EPA/DHA)

Essential fatty acids critical for brain health, cardiovascular function, and inflammation regulation. One of the most studied and recommended supplements globally.

Strong500+ studiesโ€ข85% positive
InflammationCardiovascularBrain
Magnesium
83
๐Ÿ’Ž

Magnesium

Magnesium (Glycinate/Threonate/Citrate)

The most universally recommended supplement in the longevity community. Critical for 300+ enzymatic reactions, sleep quality, muscle function, and nervous system regulation.

Strong200+ studiesโ€ข90% positive
SleepRecoveryFoundational
CoQ10
81
โค๏ธ

CoQ10

Coenzyme Q10 (Ubiquinone/Ubiquinol)

An essential mitochondrial cofactor and potent antioxidant that declines with age. The landmark Q-SYMBIO trial demonstrated a 50% reduction in major cardiovascular events in heart failure patients. Widely used for energy, heart health, and statin side effect management.

Moderate50+ studiesโ€ข80% positive
Heart HealthEnergyMitochondriaStatin SupportAnti-Aging
Berberine
74
๐ŸŒฟ

Berberine

Berberine Hydrochloride

A bioactive alkaloid found in goldenseal, barberry, and Oregon grape with strong evidence for blood sugar control and cholesterol management. Often called 'nature's metformin' due to its AMPK-activating metabolic effects.

Moderate46+ studiesโ€ข72% positive
Blood SugarCholesterolMetabolicGut HealthAMPK
Resveratrol
74
๐Ÿ‡

Resveratrol

Trans-Resveratrol

A polyphenol found in red grapes and wine that activates SIRT1 longevity pathways. The Baur et al. 2006 Nature study sparked global interest, though poor oral bioavailability (~1%) limits human translation of the compelling animal data.

Moderate40+ studiesโ€ข68% positive
LongevitySIRT1CardiovascularAntioxidant
Functional Mushrooms
68
๐Ÿ„

Functional Mushrooms

Lion's Mane, Reishi, Cordyceps, Chaga

Medicinal mushroom extracts used for cognitive enhancement (Lion's Mane), immune support (Reishi), energy (Cordyceps), and antioxidant protection (Chaga).

Moderate40+ studiesโ€ข72% positive
ImmuneCognitiveAdaptogen
Quercetin + Fisetin
68
๐Ÿงน

Quercetin + Fisetin

Quercetin & Fisetin (Senolytic Stack)

A natural senolytic combination that selectively clears senescent 'zombie' cells. Kirkland's Mayo Clinic research established quercetin as a senolytic, while Yousefzadeh showed fisetin extends lifespan ~10% in mice. First-in-human pilot data is promising.

Emerging25+ studiesโ€ข65% positive
SenolyticLongevityAnti-AgingInflammation
Astaxanthin
67
๐Ÿฆ

Astaxanthin

Astaxanthin (Carotenoid Antioxidant)

A potent carotenoid antioxidant derived from microalgae. 6000x stronger than vitamin C as an antioxidant. Supports skin, eye, and cardiovascular health.

Moderate30+ studiesโ€ข65% positive
AntioxidantSkinEyes
NAD+ (Oral NMN/NR)
65
๐Ÿ’Š

NAD+ (Oral NMN/NR)

NMN/NR Oral Supplementation

Oral NAD+ precursors (NMN or NR) that boost cellular NAD+ levels. More accessible and affordable than injectable NAD+, though bioavailability is lower.

Moderate20+ studiesโ€ข68% positive
EnergyAgingSupplement
Spermidine
62
๐Ÿ”ฌ

Spermidine

Spermidine (Polyamine)

A natural polyamine found in wheat germ that activates autophagy โ€” the body's cellular cleanup process. Emerging as a key longevity compound.

Emerging20+ studiesโ€ข55% positive
AutophagyHairLongevity
Methylene Blue
52
๐Ÿ”ต

Methylene Blue

Pharmaceutical Grade Methylene Blue

A mitochondrial electron carrier and monoamine oxidase inhibitor with cognitive-enhancing and neuroprotective properties. Used at micro-doses for brain health.

Emerging18+ studiesโ€ข48% positive
MitochondriaCognitiveNeuroprotection