Resveratrol
Trans-Resveratrol
A polyphenol found in red grapes and wine that activates SIRT1 longevity pathways. The Baur et al. 2006 Nature study sparked global interest, though poor oral bioavailability (~1%) limits human translation of the compelling animal data.
Key Research
Peer-Reviewed Evidence • 2 Citations
Resveratrol improves health and survival of mice on a high-calorie diet
Baur JA et al.•Nature•2006•PMID: 17086191
Key Finding: Landmark study: resveratrol improved survival, motor function, insulin sensitivity, and mitochondrial biogenesis in obese mice via SIRT1 activation.
View on PubMedCalorie restriction-like effects of 30 days of resveratrol in obese humans
Timmers S et al.•Cell Metab•2011•PMID: 22055504
Key Finding: First human RCT: 150mg/day mimicked caloric restriction effects — improved HOMA-IR and activated AMPK/SIRT1 in obese men.
View on PubMedCitations sourced from PubMed, Cochrane Library, and peer-reviewed journals. Study findings are summarized for accessibility. Always consult the original publication for full methodology and results.
📊 Evidence by Outcome
Strong mechanistic evidence for SIRT1/AMPK activation. Baur et al. Nature study showed improved survival in obese mice. Translation limited by ~1% oral bioavailability.
12 studies • Consistency: Moderate • Effect: Moderate
Systematic review of 19 human studies: consistently improved flow-mediated dilation, reduced LDL oxidation and inflammatory markers.
19 studies • Consistency: High • Effect: Small
👥 Community Insights
Taking 500mg trans-resveratrol with piperine daily. CRP dropped noticeably at 3-month labs.
Community member • Dubai• Verified
📋 Protocol Snapshot
Protocols are for informational purposes only. Always consult a qualified healthcare provider before starting any treatment protocol.
Where to Get It (UAE)
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Medical Disclaimer: The information on this page is for educational purposes only and is not intended as medical advice. Kamura Scores reflect a combination of research evidence, community data, and other factors — they are not clinical recommendations. Research citations are provided for reference; always consult the original publications for complete study details. Consult a qualified healthcare provider before starting, stopping, or modifying any treatment. Individual results may vary.