Quercetin + Fisetin
Quercetin & Fisetin (Senolytic Stack)
A natural senolytic combination that selectively clears senescent 'zombie' cells. Kirkland's Mayo Clinic research established quercetin as a senolytic, while Yousefzadeh showed fisetin extends lifespan ~10% in mice. First-in-human pilot data is promising.
Key Research
Peer-Reviewed Evidence • 3 Citations
The Achilles' heel of senescent cells: from transcriptome to senolytic drugs
Zhu Y, Kirkland JL et al.•Aging Cell•2015•PMID: 25754370
Key Finding: Foundational senolytic paper: dasatinib + quercetin selectively killed senescent cells, extending healthspan in aged mice.
View on PubMedFisetin is a senotherapeutic that extends health and lifespan
Yousefzadeh MJ et al.•EBioMedicine•2018•PMID: 30279143
Key Finding: Fisetin extended median lifespan ~10% in wild-type mice and reduced senescent cell burden.
View on PubMedSenolytics in idiopathic pulmonary fibrosis: first-in-human pilot
Justice JN, Kirkland JL et al.•EBioMedicine•2019•PMID: 30616998
Key Finding: First human senolytic study (n=14): D+Q improved 6-minute walk distance, chair-stand time, and gait speed in IPF patients.
View on PubMedCitations sourced from PubMed, Cochrane Library, and peer-reviewed journals. Study findings are summarized for accessibility. Always consult the original publication for full methodology and results.
📊 Evidence by Outcome
Strong preclinical evidence from Kirkland/Mayo. First-in-human pilot (n=14) showed functional improvements. Intermittent 'hit and run' dosing protocol is key.
15 studies • Consistency: High • Effect: Large
IPF pilot showed improved 6-minute walk distance (+21.5m) and chair-stand time consistent with senescent cell reduction.
3 studies • Consistency: Moderate • Effect: Moderate
👥 Community Insights
Doing the 2-day senolytic protocol monthly (1g quercetin + 500mg fisetin). Feel noticeably more energized the week after.
Community member • USA• Verified
📋 Protocol Snapshot
Protocols are for informational purposes only. Always consult a qualified healthcare provider before starting any treatment protocol.
Where to Get It (UAE)
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Medical Disclaimer: The information on this page is for educational purposes only and is not intended as medical advice. Kamura Scores reflect a combination of research evidence, community data, and other factors — they are not clinical recommendations. Research citations are provided for reference; always consult the original publications for complete study details. Consult a qualified healthcare provider before starting, stopping, or modifying any treatment. Individual results may vary.