Quercetin + Fisetin
Quercetin & Fisetin (Senolytic Stack)
A natural senolytic combination that selectively clears senescent 'zombie' cells. Kirkland's Mayo Clinic research established quercetin as a senolytic, while Yousefzadeh showed fisetin extends lifespan ~10% in mice. First-in-human pilot data is promising.
How Quercetin + Fisetin Works
Quercetin and fisetin are flavonoid polyphenols that function as senolytics — compounds that selectively induce apoptosis (programmed cell death) in senescent cells that accumulate with aging and drive chronic inflammation. Fisetin is one of the most potent natural senolytics identified in preclinical screening. Both compounds also inhibit NF-kB signaling to reduce inflammation, activate SIRT1 for metabolic and longevity benefits, and modulate mTOR to promote autophagy. Their combined use targets multiple hallmarks of aging simultaneously.
📊 Evidence by Outcome
Strong preclinical evidence from Kirkland/Mayo. First-in-human pilot (n=14) showed functional improvements. Intermittent 'hit and run' dosing protocol is key.
15 studies • Consistency: High • Effect: Large
IPF pilot showed improved 6-minute walk distance (+21.5m) and chair-stand time consistent with senescent cell reduction.
3 studies • Consistency: Moderate • Effect: Moderate
Key Research
Peer-Reviewed Evidence • 3 Citations
The Achilles' heel of senescent cells: from transcriptome to senolytic drugs
Zhu Y, Kirkland JL et al.•Aging Cell•2015•PMID: 25754370
Key Finding: Foundational senolytic paper: dasatinib + quercetin selectively killed senescent cells, extending healthspan in aged mice.
View on PubMedFisetin is a senotherapeutic that extends health and lifespan
Yousefzadeh MJ et al.•EBioMedicine•2018•PMID: 30279143
Key Finding: Fisetin extended median lifespan ~10% in wild-type mice and reduced senescent cell burden.
View on PubMedSenolytics in idiopathic pulmonary fibrosis: first-in-human pilot
Justice JN, Kirkland JL et al.•EBioMedicine•2019•PMID: 30616998
Key Finding: First human senolytic study (n=14): D+Q improved 6-minute walk distance, chair-stand time, and gait speed in IPF patients.
View on PubMedCitations sourced from PubMed, Cochrane Library, and peer-reviewed journals. Study findings are summarized for accessibility. Always consult the original publication for full methodology and results.
Side Effects & Safety
Interactions & Contraindications
Drug Interactions
- •Antibiotics (fluoroquinolones such as ciprofloxacin) — quercetin may interfere with absorption
- •Cyclosporine — quercetin inhibits CYP3A4, raising cyclosporine levels
- •Blood thinners — both compounds have mild antiplatelet effects
- •Chemotherapy drugs — may alter drug efficacy; consult oncologist before combining
- •Thyroid medications — high-dose quercetin may interfere with thyroid hormone synthesis
Supplement Interactions
- •Vitamin C — enhances quercetin absorption and recycling
- •Bromelain — commonly combined to improve quercetin bioavailability
- •Resveratrol — synergistic activation of sirtuin and senolytic pathways
- •Dasatinib (prescription) — the dasatinib + quercetin/fisetin protocol is a leading senolytic research combination
Food & Timing
- •Fat-containing meals — improve absorption of both flavonoids
- •Onions, apples, and berries — natural dietary sources that add to total flavonoid intake
Who Should Avoid
- •Patients undergoing chemotherapy without oncologist approval
- •Severe kidney disease (particularly for high-dose fisetin)
- •Thyroid disorders at very high quercetin doses
- •Pregnancy and breastfeeding — insufficient safety data for supplement doses
📋 Protocol Snapshot
Protocols are for informational purposes only. Always consult a qualified healthcare provider before starting any treatment protocol.
Cost Guide
AED 120-350/month
Estimated UAE pricing. Costs vary by provider, dosage, and treatment plan.
Frequently Asked Questions
Senolytics are compounds that clear senescent (zombie) cells — old, damaged cells that stop dividing but refuse to die, secreting inflammatory signals that accelerate aging. Clearing these cells has been shown to improve healthspan in animal models. Quercetin and fisetin are among the most studied natural senolytics.
They are often taken together in senolytic protocols, typically in periodic high-dose cycles (e.g., 2-3 consecutive days per month) rather than daily low doses. For daily antioxidant support, quercetin alone at 500-1,000 mg is common. Consult a longevity-focused physician for protocol guidance.
Quercetin is widely available in UAE pharmacies and health stores. Fisetin is less common but can be found through online supplement retailers that ship to the UAE. Both are sold as over-the-counter supplements.
For daily antioxidant use, quercetin 500-1,000 mg with vitamin C is typical. For senolytic protocols, higher intermittent doses of fisetin (up to 20 mg/kg bodyweight for 2 days) have been studied clinically, but these should be done under medical guidance.
Where to Get It (UAE)
Related Treatments
Medical Disclaimer: The information on this page is for educational purposes only and is not intended as medical advice. Kamura Scores reflect a combination of research evidence, safety, accessibility, and value — they are not clinical recommendations. Research citations are provided for reference; always consult the original publications for complete study details. Consult a qualified healthcare provider before starting, stopping, or modifying any treatment. Individual results may vary.