Nicotinamide Riboside
Nicotinamide Riboside (NR)
An NAD+ precursor vitamin (form of B3) that efficiently raises cellular NAD+ levels. More clinical trial data than NMN, with demonstrated benefits for cardiovascular health, brain function, and metabolic optimization. The basis for Tru Niagen, one of the best-selling longevity supplements.
How Nicotinamide Riboside Works
NR is converted to NMN by nicotinamide riboside kinases (NRK1/2), then to NAD+ by NMNAT enzymes. Supports sirtuin activation, PARP-mediated DNA repair, and mitochondrial function.
📊 Evidence by Outcome
Multiple human RCTs confirm 40-90% increase in blood NAD+ within 2 weeks of supplementation at 300-1000mg/day.
15 studies • Consistency: High • Effect: Large
Reduced arterial stiffness and improved blood pressure in older adults. Promising data for heart failure patients.
8 studies • Consistency: Moderate • Effect: Moderate
Animal data strong for Alzheimer's and Parkinson's models. Human cognitive trials ongoing.
10 studies • Consistency: Mixed • Effect: Unclear
Key Research
Peer-Reviewed Evidence • 1 Citations
Chronic NR supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults
Martens CR et al.•Nature Communications•2018•PMID: 29599478
Key Finding: 1000mg/day NR for 6 weeks safely raised NAD+ by 60% and reduced arterial stiffness and blood pressure in healthy older adults.
View on PubMedCitations sourced from PubMed, Cochrane Library, and peer-reviewed journals. Study findings are summarized for accessibility. Always consult the original publication for full methodology and results.
📋 Protocol Snapshot
Protocols are for informational purposes only. Always consult a qualified healthcare provider before starting any treatment protocol.
Cost Guide
AED 250-600/month
Estimated UAE pricing. Costs vary by provider, dosage, and treatment plan.
Where to Get It (UAE)
Related Treatments
Medical Disclaimer: The information on this page is for educational purposes only and is not intended as medical advice. Kamura Scores reflect a combination of research evidence, community data, and other factors — they are not clinical recommendations. Research citations are provided for reference; always consult the original publications for complete study details. Consult a qualified healthcare provider before starting, stopping, or modifying any treatment. Individual results may vary.