Apigenin
A natural flavonoid found in chamomile, celery, and parsley. Part of Andrew Huberman's nightly sleep stack. Promotes sleep quality through mild anxiolytic effects and CD38 inhibition (preserving NAD+ levels).
How Apigenin Works
Apigenin binds to GABA-A receptors as a positive allosteric modulator, producing mild anxiolytic and sedative effects. It also inhibits CD38 (an NAD+-consuming enzyme), potentially preserving cellular NAD+ levels.
📊 Evidence by Outcome
Mild sedative and anxiolytic effects through GABA modulation. Part of Huberman's recommended sleep stack alongside magnesium and L-theanine.
8 studies • Consistency: Moderate • Effect: Small-Moderate
Inhibits CD38, an enzyme that degrades NAD+. May help preserve NAD+ levels synergistically with NMN/NR supplementation.
5 studies • Consistency: Mixed • Effect: Unclear
Key Research
Peer-Reviewed Evidence • 1 Citations
Apigenin: a promising molecule for cancer prevention
Shukla S et al.•Pharmaceutical Research•2010•PMID: 20232117
Key Finding: Review of apigenin's biological activities including anti-inflammatory, antioxidant, and anxiolytic effects through GABA receptor modulation.
View on PubMedCitations sourced from PubMed, Cochrane Library, and peer-reviewed journals. Study findings are summarized for accessibility. Always consult the original publication for full methodology and results.
📋 Protocol Snapshot
Protocols are for informational purposes only. Always consult a qualified healthcare provider before starting any treatment protocol.
Cost Guide
AED 40-100/month
Estimated UAE pricing. Costs vary by provider, dosage, and treatment plan.
Where to Get It (UAE)
Related Treatments
Medical Disclaimer: The information on this page is for educational purposes only and is not intended as medical advice. Kamura Scores reflect a combination of research evidence, community data, and other factors — they are not clinical recommendations. Research citations are provided for reference; always consult the original publications for complete study details. Consult a qualified healthcare provider before starting, stopping, or modifying any treatment. Individual results may vary.