Spermidine
Spermidine (Polyamine)
A natural polyamine found in wheat germ that activates autophagy — the body's cellular cleanup process. Emerging as a key longevity compound.
Key Research
Peer-Reviewed Evidence • 3 Citations
Cardioprotection and lifespan extension by the natural polyamine spermidine
Eisenberg T et al.•Nat Med•2016•PMID: 27841876
Key Finding: Dietary spermidine supplementation reduced cardiac aging, improved diastolic function, and extended lifespan in mice and humans.
View on PubMedHigher spermidine intake is linked to lower mortality: A prospective population-based study
Kiechl S et al.•Am J Clin Nutr•2018•PMID: 30215711
Key Finding: Prospective study of 829 participants showed highest tertile of spermidine intake associated with significantly reduced all-cause mortality.
View on PubMedSpermidine in health and disease
Madeo F et al.•Science•2018•PMID: 29371440
Key Finding: Spermidine induces autophagy and has anti-aging properties, with epidemiological evidence supporting its role in cardiovascular and neurological health.
View on PubMedCitations sourced from PubMed, Cochrane Library, and peer-reviewed journals. Study findings are summarized for accessibility. Always consult the original publication for full methodology and results.
📊 Evidence by Outcome
Induces autophagy similar to fasting. Observational data links high spermidine intake to longevity.
12 studies • Consistency: Moderate • Effect: Moderate
Small studies suggest hair follicle prolongation. Community reports mixed.
4 studies • Consistency: Mixed • Effect: Small
👥 Community Insights
Taking it as part of my longevity stack. Hard to measure but aligns with the science.
Community member • Dubai• Verified
📋 Protocol Snapshot
Protocols are for informational purposes only. Always consult a qualified healthcare provider before starting any treatment protocol.
Where to Get It (UAE)
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Medical Disclaimer: The information on this page is for educational purposes only and is not intended as medical advice. Kamura Scores reflect a combination of research evidence, community data, and other factors — they are not clinical recommendations. Research citations are provided for reference; always consult the original publications for complete study details. Consult a qualified healthcare provider before starting, stopping, or modifying any treatment. Individual results may vary.