Alpha-Ketoglutarate (AKG)
Alpha-Ketoglutarate
Key metabolic intermediate in the Krebs cycle that reduces inflammation, supports mitochondrial function, and extended lifespan 12% in mice. Bryan Johnson includes calcium-AKG in his stack.
How Alpha-Ketoglutarate (AKG) Works
AKG is a central Krebs cycle metabolite that declines with age. Supplementation supports mitochondrial energy production, inhibits TOR signaling, promotes collagen synthesis, and serves as a nitrogen scavenger.
📊 Evidence by Outcome
Extended lifespan 12% and reduced biological age markers in mice. Human RCT (Rejuvant) showed 8-year reduction in biological age.
5 studies • Consistency: Moderate • Effect: Moderate
Reduces chronic low-grade inflammation through multiple metabolic pathways.
6 studies • Consistency: Moderate • Effect: Moderate
Key Research
Peer-Reviewed Evidence • 1 Citations
Alpha-ketoglutarate extends lifespan in C57BL/6 mice
Asadi Shahmirzadi A et al.•Cell Metabolism•2020•PMID: 32877690
Key Finding: Ca-AKG extended median lifespan by 12% in female mice, reduced frailty index, and improved mTOR pathway signaling.
View on PubMedCitations sourced from PubMed, Cochrane Library, and peer-reviewed journals. Study findings are summarized for accessibility. Always consult the original publication for full methodology and results.
📋 Protocol Snapshot
Protocols are for informational purposes only. Always consult a qualified healthcare provider before starting any treatment protocol.
Cost Guide
AED 100-250/month
Estimated UAE pricing. Costs vary by provider, dosage, and treatment plan.
Where to Get It (UAE)
Related Treatments
Medical Disclaimer: The information on this page is for educational purposes only and is not intended as medical advice. Kamura Scores reflect a combination of research evidence, community data, and other factors — they are not clinical recommendations. Research citations are provided for reference; always consult the original publications for complete study details. Consult a qualified healthcare provider before starting, stopping, or modifying any treatment. Individual results may vary.