Urolithin A
A postbiotic metabolite that activates mitophagy — the selective recycling of damaged mitochondria. Originally derived from pomegranates and walnuts via gut bacteria, now available as a supplement (Mitopure). Strong clinical evidence for muscle strength and mitochondrial health in aging.
How Urolithin A Works
Urolithin A activates the PINK1/Parkin mitophagy pathway, tagging damaged mitochondria for selective degradation. This triggers compensatory mitochondrial biogenesis, resulting in a rejuvenated, more efficient mitochondrial population.
📊 Evidence by Outcome
Uniquely activates mitophagy pathways, clearing damaged mitochondria and promoting biogenesis of healthy replacements.
8 studies • Consistency: High • Effect: Large
Improved muscle strength and exercise endurance in older adults after 4 months. Significant improvement in 6-minute walk test.
5 studies • Consistency: Moderate • Effect: Moderate
Key Research
Peer-Reviewed Evidence • 1 Citations
Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health
Singh A et al.•Cell Reports Medicine•2022•PMID: 35243422
Key Finding: 4 months of Urolithin A (1000mg/day) improved leg muscle strength, 6-minute walk distance, and plasma biomarkers of mitochondrial health in middle-aged adults.
View on PubMedCitations sourced from PubMed, Cochrane Library, and peer-reviewed journals. Study findings are summarized for accessibility. Always consult the original publication for full methodology and results.
📋 Protocol Snapshot
Protocols are for informational purposes only. Always consult a qualified healthcare provider before starting any treatment protocol.
Cost Guide
AED 350-700/month
Estimated UAE pricing. Costs vary by provider, dosage, and treatment plan.
Where to Get It (UAE)
Related Treatments
Medical Disclaimer: The information on this page is for educational purposes only and is not intended as medical advice. Kamura Scores reflect a combination of research evidence, community data, and other factors — they are not clinical recommendations. Research citations are provided for reference; always consult the original publications for complete study details. Consult a qualified healthcare provider before starting, stopping, or modifying any treatment. Individual results may vary.