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Best Anti-Aging Treatments

Rejuvenation therapies, cellular repair, and age-reversal protocols. Scored on geroscience research and biological markers.

16 treatmentsAvg. score: 70/100
Retatrutide
89
GLP-1 & Weight Management
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Retatrutide

Retatrutide (LY3437943)

A triple-agonist peptide (GIP/GLP-1/Glucagon receptor) showing the most dramatic weight loss results in clinical trials — up to 24% body weight reduction. Also showing anti-aging effects beyond weight loss.

Strong15+ studies97% positive
Weight LossAnti-AgingMetabolic
GHK-Cu
86
Peptides

GHK-Cu

Copper Peptide GHK-Cu

A naturally occurring copper peptide with remarkable anti-aging, hair growth, and skin rejuvenation properties. Known for reversing grey hair and improving skin elasticity.

Moderate45+ studies92% positive
HairSkinAnti-Aging
Metformin
82
Longevity Pharmaceuticals
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Metformin

Metformin Hydrochloride (Off-Label Longevity)

A first-line diabetes drug with 60+ years of clinical history, now emerging as the most evidence-backed pharmaceutical for anti-aging. The Bannister study showed metformin users outliving non-diabetic controls, and the TAME trial is the first FDA-approved trial targeting aging itself.

Strong53+ studies78% positive
LongevityAnti-AgingCardiovascularCancer PreventionMetabolic
CJC-1295 + Ipamorelin
81
Peptides
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CJC-1295 + Ipamorelin

CJC-1295 with Ipamorelin Stack

A synergistic peptide combination that stimulates natural growth hormone release. Widely used for anti-aging, body composition improvement, and recovery enhancement.

Moderate35+ studies85% positive
Growth HormoneAnti-AgingRecovery
CoQ10
81
Supplements & Nutraceuticals
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CoQ10

Coenzyme Q10 (Ubiquinone/Ubiquinol)

An essential mitochondrial cofactor and potent antioxidant that declines with age. The landmark Q-SYMBIO trial demonstrated a 50% reduction in major cardiovascular events in heart failure patients. Widely used for energy, heart health, and statin side effect management.

Moderate50+ studies80% positive
Heart HealthEnergyMitochondriaStatin SupportAnti-Aging
HIIT / Functional Training
78
Mind-Body & Movement

HIIT / Functional Training

High-Intensity Interval Training & Functional Movement

High-Intensity Interval Training (HIIT) involves short bursts of all-out exercise alternated with brief recovery periods, while functional training emphasizes natural movement patterns. HIIT has one of the strongest evidence bases in exercise science for metabolic health, cardiovascular fitness, and longevity benefits. Widely available across UAE gyms, outdoor boot camps, and boutique studios including F45, Barry's, and outdoor fitness groups.

Strong450+ studies85% positive
ExerciseCardioMetabolic HealthLongevityFat LossMitochondria
NAD+ (Injectable)
74
IV & Infusion Therapies
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NAD+ (Injectable)

Nicotinamide Adenine Dinucleotide (IV/SubQ)

Direct NAD+ supplementation via IV or subcutaneous injection. Bypasses oral bioavailability issues to rapidly restore cellular NAD+ levels for energy, DNA repair, and anti-aging.

Moderate25+ studies80% positive
EnergyAgingCellular Health
Rapamycin
73
Longevity Pharmaceuticals
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Rapamycin

Rapamycin (Sirolimus) for Longevity

An mTOR inhibitor originally used in organ transplant patients, now emerging as the most evidence-backed pharmacological longevity intervention. The landmark Harrison 2009 study showed lifespan extension in mice, and the PEARL trial (2025) confirmed safety in healthy adults at longevity doses.

Strong80+ studies75% positive
LongevityAnti-AgingmTORImmuneGeroprotective
Growth Hormone
72
Hormones
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Growth Hormone

Human Growth Hormone (HGH)

Recombinant human growth hormone used for anti-aging and body composition. Expensive and requires careful monitoring but has well-documented effects on lean mass and fat reduction.

Strong100+ studies70% positive
Anti-AgingRecoveryBody Composition
Hyperbaric Oxygen
71
Devices & Technology
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Hyperbaric Oxygen

Hyperbaric Oxygen Therapy (HBOT)

Breathing pure oxygen at elevated atmospheric pressure to increase oxygen delivery to tissues. Used for wound healing, cognitive enhancement, and emerging anti-aging applications.

Moderate50+ studies68% positive
Wound HealingCognitiveAnti-Aging
Quercetin + Fisetin
68
Supplements & Nutraceuticals
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Quercetin + Fisetin

Quercetin & Fisetin (Senolytic Stack)

A natural senolytic combination that selectively clears senescent 'zombie' cells. Kirkland's Mayo Clinic research established quercetin as a senolytic, while Yousefzadeh showed fisetin extends lifespan ~10% in mice. First-in-human pilot data is promising.

Emerging25+ studies65% positive
SenolyticLongevityAnti-AgingInflammation
Stem Cell Therapy
64
Regenerative Medicine
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Stem Cell Therapy

Mesenchymal Stem Cell Therapy

Regenerative medicine using stem cells (MSCs) for joint repair, anti-aging, and tissue regeneration. Rapidly advancing field with promising but variable results.

Emerging30+ studies65% positive
RegenerationJointAnti-Aging
SS-31
60
Peptides

SS-31

Elamipretide / SS-31

A mitochondria-targeted peptide that stabilizes cardiolipin and restores electron transport chain function. Investigated for age-related mitochondrial dysfunction.

Emerging20+ studies50% positive
MitochondriaEnergyAnti-Aging
Epitalon
55
Peptides
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Epitalon

Epithalon / Epithalamin

A tetrapeptide that activates telomerase, the enzyme responsible for maintaining telomere length. One of the most intriguing anti-aging peptides with decades of Russian research.

Emerging15+ studies55% positive
TelomeresAnti-AgingLongevity
Senolytics
55
Longevity Pharmaceuticals
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Senolytics

Senolytic Compounds (Dasatinib + Quercetin, Fisetin, Navitoclax)

A class of drugs and natural compounds that selectively eliminate senescent ("zombie") cells, which accumulate with age and drive chronic inflammation, tissue dysfunction, and age-related disease. The most studied combination is dasatinib plus quercetin (D+Q), while fisetin is emerging as a well-tolerated plant-derived alternative. Human trials are underway, but senolytics remain a frontier longevity intervention with significant promise and limited long-term safety data.

Emerging85+ studies62% positive
LongevityAnti-AgingCellular HealthInflammationSenescence
Plasma Dilution
35
Longevity Pharmaceuticals
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Plasma Dilution

Therapeutic Plasma Exchange & Neutral Blood Exchange

An experimental rejuvenation approach based on the hypothesis that aging is driven partly by accumulated pro-aging factors in blood plasma. Therapeutic plasma exchange (TPE) or neutral blood exchange (NBE) replaces a portion of blood plasma with saline and albumin, diluting these factors. Pioneered by the Conboy lab at UC Berkeley, early animal studies showed remarkable tissue rejuvenation, but human longevity data remains very limited.

Emerging18+ studies50% positive
LongevityAnti-AgingBloodExperimentalRejuvenation
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