Acarbose
An alpha-glucosidase inhibitor that slows carbohydrate digestion, blunting post-meal glucose spikes. Validated by the NIA Interventions Testing Program for lifespan extension in mice. Bryan Johnson takes 200mg daily as part of his Blueprint protocol.
How Acarbose Works
Acarbose competitively inhibits alpha-glucosidase enzymes in the small intestine, slowing the breakdown of complex carbohydrates into glucose. This delays glucose absorption, reducing post-prandial glycemic excursions and downstream insulin spikes.
📊 Evidence by Outcome
NIA ITP: Extended median lifespan in male mice by 11%. One of only a handful of ITP-validated longevity drugs.
3 studies • Consistency: Moderate • Effect: Moderate
Reduces post-prandial glucose spikes by 20-30%. Well-established as a Type 2 diabetes medication.
20 studies • Consistency: High • Effect: Large
STOP-NIDDM trial: 49% relative risk reduction in cardiovascular events in IGT patients.
5 studies • Consistency: Moderate • Effect: Moderate
Key Research
Peer-Reviewed Evidence • 1 Citations
Acarbose improves health and lifespan in aging HET3 mice
Harrison DE et al.•Aging Cell•2019•PMID: 30548460
Key Finding: NIA Interventions Testing Program confirmed acarbose extends median lifespan by 11% in male mice. Effects partially mediated through reduced post-prandial glucose.
View on PubMedCitations sourced from PubMed, Cochrane Library, and peer-reviewed journals. Study findings are summarized for accessibility. Always consult the original publication for full methodology and results.
Side Effects & Safety
📋 Protocol Snapshot
Protocols are for informational purposes only. Always consult a qualified healthcare provider before starting any treatment protocol.
Cost Guide
AED 50-150/month (prescription)
Estimated UAE pricing. Costs vary by provider, dosage, and treatment plan.
Where to Get It (UAE)
Related Treatments
Medical Disclaimer: The information on this page is for educational purposes only and is not intended as medical advice. Kamura Scores reflect a combination of research evidence, community data, and other factors — they are not clinical recommendations. Research citations are provided for reference; always consult the original publications for complete study details. Consult a qualified healthcare provider before starting, stopping, or modifying any treatment. Individual results may vary.