SGLT2 Inhibitors
Sodium-Glucose Cotransporter 2 Inhibitors
A class of diabetes drugs (empagliflozin, dapagliflozin, canagliflozin) that promote glucose excretion through urine. NIA Interventions Testing Program validated for lifespan extension. Emerging as senotherapeutic agents with cardiovascular and kidney protective effects.
How SGLT2 Inhibitors Works
SGLT2 inhibitors block glucose reabsorption in the kidney, causing glycosuria (glucose in urine). This mimics caloric restriction metabolically, activates AMPK, reduces insulin levels, and triggers autophagy — all mechanisms linked to longevity.
📊 Evidence by Outcome
NIA ITP: Canagliflozin extended median lifespan by 14% in male mice. One of the most promising longevity drug candidates.
3 studies • Consistency: Moderate • Effect: Moderate
Landmark trials (EMPA-REG, DAPA-HF): 35% reduction in heart failure hospitalization. Benefits extend beyond glucose control.
30 studies • Consistency: High • Effect: Large
DAPA-CKD: 39% reduction in kidney disease progression. Now FDA-approved for chronic kidney disease regardless of diabetes status.
15 studies • Consistency: High • Effect: Large
Key Research
Peer-Reviewed Evidence • 1 Citations
Canagliflozin extends lifespan in genetically heterogeneous male mice
Miller RA et al.•JCI Insight•2020•PMID: 31999643
Key Finding: NIA ITP confirmed canagliflozin extends median lifespan by 14% in male mice, with reduced fat mass and improved metabolic markers.
View on PubMedCitations sourced from PubMed, Cochrane Library, and peer-reviewed journals. Study findings are summarized for accessibility. Always consult the original publication for full methodology and results.
Side Effects & Safety
📋 Protocol Snapshot
Protocols are for informational purposes only. Always consult a qualified healthcare provider before starting any treatment protocol.
Cost Guide
AED 200-500/month (prescription)
Estimated UAE pricing. Costs vary by provider, dosage, and treatment plan.
Where to Get It (UAE)
Related Treatments
Medical Disclaimer: The information on this page is for educational purposes only and is not intended as medical advice. Kamura Scores reflect a combination of research evidence, community data, and other factors — they are not clinical recommendations. Research citations are provided for reference; always consult the original publications for complete study details. Consult a qualified healthcare provider before starting, stopping, or modifying any treatment. Individual results may vary.