Retatrutide
Retatrutide (LY3437943)
A triple-agonist peptide (GIP/GLP-1/Glucagon receptor) showing the most dramatic weight loss results in clinical trials — up to 24% body weight reduction. Also showing anti-aging effects beyond weight loss.
Key Research
Peer-Reviewed Evidence • 3 Citations
Retatrutide, a GIP, GLP-1 and glucagon receptor triple agonist, for people with type 2 diabetes and obesity
Rosenstock J et al.•Lancet•2023•PMID: 37385278
Key Finding: Retatrutide achieved up to 24% body weight loss at 48 weeks — the highest weight reduction reported for any obesity drug to date.
View on PubMedTriple hormone receptor agonist retatrutide for metabolic dysfunction-associated steatotic liver disease
Sanyal AJ et al.•N Engl J Med•2024•PMID: 38587239
Key Finding: Retatrutide resolved metabolic liver disease (MASLD) in up to 90% of participants, with significant reductions in liver fat.
View on PubMedGIP/GLP-1/glucagon triple receptor agonism: A new frontier in metabolic disease treatment
Coskun T et al.•Mol Metab•2022•PMID: 35421636
Key Finding: Triple receptor agonism produces synergistic metabolic benefits superior to dual agonists, targeting obesity, diabetes, and liver disease simultaneously.
View on PubMedCitations sourced from PubMed, Cochrane Library, and peer-reviewed journals. Study findings are summarized for accessibility. Always consult the original publication for full methodology and results.
📊 Evidence by Outcome
Phase 2 trial showed 24.2% body weight loss at highest dose. Most effective weight loss drug ever tested.
5 studies • Consistency: High • Effect: Very Large
Community reports of significant biomarker improvements. Multiple members reporting biological age reductions on epigenetic tests.
2 studies • Consistency: Moderate • Effect: Large
Dramatic improvements in insulin sensitivity, triglycerides, and liver fat.
5 studies • Consistency: High • Effect: Large
👥 Community Insights
Lost 15kg in 3 months. Blood work dramatically improved across the board.
Community member • Dubai• Verified
Biological age dropped 8 years on TruAge test after 6 months.
Community member • Dubai• Verified
📋 Protocol Snapshot
Protocols are for informational purposes only. Always consult a qualified healthcare provider before starting any treatment protocol.
Where to Get It (UAE)
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Medical Disclaimer: The information on this page is for educational purposes only and is not intended as medical advice. Kamura Scores reflect a combination of research evidence, community data, and other factors — they are not clinical recommendations. Research citations are provided for reference; always consult the original publications for complete study details. Consult a qualified healthcare provider before starting, stopping, or modifying any treatment. Individual results may vary.