Growth Hormone
Human Growth Hormone (HGH)
Recombinant human growth hormone used for anti-aging and body composition. Expensive and requires careful monitoring but has well-documented effects on lean mass and fat reduction.
How Growth Hormone Works
Recombinant human growth hormone (rhGH) binds to GH receptors on hepatocytes, stimulating production of insulin-like growth factor 1 (IGF-1), the primary mediator of GH's anabolic effects. IGF-1 drives protein synthesis, lipolysis, and cellular regeneration across muscle, bone, and connective tissue. GH also directly stimulates chondrocyte proliferation and has lipolytic effects on adipose tissue, reducing visceral fat while promoting lean mass accretion.
📊 Evidence by Outcome
Well-established improvements in lean mass and fat reduction in GH-deficient adults.
30 studies • Consistency: High • Effect: Large
Reported improvements in skin thickness and hair quality.
10 studies • Consistency: Moderate • Effect: Moderate
Paradoxical — low IGF-1 associated with longevity in centenarian studies. Long-term anti-aging benefits uncertain.
15 studies • Consistency: Mixed • Effect: Unclear
Key Research
Peer-Reviewed Evidence • 3 Citations
Growth hormone therapy and the risk of cancer in adults: A systematic review and meta-analysis
Li Z et al.•J Clin Endocrinol Metab•2022•PMID: 35259264
Key Finding: Meta-analysis of 18 studies found no significant association between GH therapy and increased cancer risk in adults with GH deficiency.
View on PubMedGrowth hormone replacement in healthy older men improves body composition but not functional ability
Blackman MR et al.•JAMA•2002•PMID: 12425705
Key Finding: GH with sex steroids increased lean mass and decreased fat mass in older adults, but improvements in functional outcomes were limited.
View on PubMedReversing the metabolic syndrome with combination growth hormone and testosterone replacement therapy
Johannsson G et al.•J Clin Endocrinol Metab•2009•PMID: 19494158
Key Finding: Combined GH and testosterone therapy in men with metabolic syndrome produced significant improvements in body composition, insulin sensitivity, and lipid profiles.
View on PubMedCitations sourced from PubMed, Cochrane Library, and peer-reviewed journals. Study findings are summarized for accessibility. Always consult the original publication for full methodology and results.
Side Effects & Safety
Interactions & Contraindications
Drug Interactions
- •May reduce insulin sensitivity — diabetics should adjust dosing with physician oversight
- •Corticosteroids may blunt GH efficacy
- •Thyroid hormone requirements may increase during GH therapy
Supplement Interactions
- •Synergistic with peptide secretagogues (CJC-1295, Ipamorelin) for pulsatile release
- •Arginine and ornithine may mildly potentiate natural GH secretion
- •Melatonin at bedtime may enhance nocturnal GH pulse
Food & Timing
- •Best administered on an empty stomach — insulin blunts GH release
- •Avoid high-glycemic meals within 1 hour of injection
Who Should Avoid
- •Active cancer or history of malignancy within 5 years
- •Diabetic retinopathy
- •Uncontrolled diabetes mellitus
- •Active proliferative retinopathy
- •Closed epiphyses in pediatric use (for growth purposes)
📋 Protocol Snapshot
Protocols are for informational purposes only. Always consult a qualified healthcare provider before starting any treatment protocol.
Cost Guide
AED 2,500–5,000/month
Estimated UAE pricing. Costs vary by provider, dosage, and treatment plan.
Frequently Asked Questions
Yes, GH therapy is legally available in the UAE when prescribed by a licensed endocrinologist or anti-aging physician. Clinics in Dubai and Abu Dhabi offer it as part of hormone optimization protocols. A prescription is required and therapy is monitored through regular blood work.
Most patients notice improved sleep quality and recovery within 2-4 weeks. Body composition changes (fat loss, lean mass) typically become visible at 3-6 months. Skin and hair improvements are often reported around the 3-month mark.
Key markers include IGF-1 levels (target the upper-normal range for your age), fasting glucose, HbA1c, thyroid panel (free T3, free T4, TSH), and a comprehensive metabolic panel. Testing every 8-12 weeks is standard practice in UAE longevity clinics.
Current evidence does not show that GH therapy causes new cancers in individuals without pre-existing malignancies. However, GH can accelerate the growth of existing tumors due to its proliferative effects via IGF-1. Cancer screening before starting therapy is strongly recommended.
Where to Get It (UAE)
Related Treatments
Medical Disclaimer: The information on this page is for educational purposes only and is not intended as medical advice. Kamura Scores reflect a combination of research evidence, safety, accessibility, and value — they are not clinical recommendations. Research citations are provided for reference; always consult the original publications for complete study details. Consult a qualified healthcare provider before starting, stopping, or modifying any treatment. Individual results may vary.