Caloric Restriction
Caloric Restriction (CR)
The most researched longevity intervention in history — a sustained 10-30% reduction in caloric intake without malnutrition. Extends lifespan in nearly every organism tested, from yeast to primates. The CALERIE human trial confirmed metabolic and aging benefits.
How Caloric Restriction Works
CR activates multiple longevity pathways simultaneously: AMPK activation, mTOR inhibition, sirtuin activation, autophagy enhancement, reduced insulin/IGF-1 signaling, decreased inflammation, and improved mitochondrial efficiency. These converge to slow the pace of biological aging.
📊 Evidence by Outcome
CALERIE trial: 25% CR for 2 years slowed biological aging by 2-3% per year measured by DunedinPACE epigenetic clock.
5 studies • Consistency: High • Effect: Large
Reduces fasting glucose, insulin, blood pressure, cholesterol, inflammation (CRP), and oxidative stress markers.
20 studies • Consistency: High • Effect: Large
Extends lifespan 20-50% in rodents, 10-20% in primates. The most consistently replicated longevity intervention across species.
200 studies • Consistency: High • Effect: Very Large
Key Research
Peer-Reviewed Evidence • 1 Citations
Caloric restriction slows biological aging in the CALERIE trial
Waziry R et al.•Nature Aging•2023•PMID: 37118425
Key Finding: 2-year 25% caloric restriction in non-obese adults slowed the pace of biological aging by 2-3% per year as measured by the DunedinPACE epigenetic clock.
View on PubMedCitations sourced from PubMed, Cochrane Library, and peer-reviewed journals. Study findings are summarized for accessibility. Always consult the original publication for full methodology and results.
📋 Protocol Snapshot
Protocols are for informational purposes only. Always consult a qualified healthcare provider before starting any treatment protocol.
Cost Guide
Free (may reduce food costs)
Estimated UAE pricing. Costs vary by provider, dosage, and treatment plan.
Related Treatments
Medical Disclaimer: The information on this page is for educational purposes only and is not intended as medical advice. Kamura Scores reflect a combination of research evidence, safety, accessibility, and value — they are not clinical recommendations. Research citations are provided for reference; always consult the original publications for complete study details. Consult a qualified healthcare provider before starting, stopping, or modifying any treatment. Individual results may vary.