17-α-Estradiol
17-Alpha-Estradiol (Non-Feminizing Estrogen)
Non-feminizing form of estradiol that has extended lifespan in male mice by ~19% in the NIA Interventions Testing Program. Unlike 17-β-estradiol, it does not cause feminizing effects. Mechanism involves metabolic improvements and mTOR pathway modulation.
📊 Evidence by Outcome
Extended lifespan (mice)
3 studies • Consistency: Moderate • Effect: Moderate
Improved metabolic health
3 studies • Consistency: Moderate • Effect: Moderate
Reduced inflammation
3 studies • Consistency: Moderate • Effect: Moderate
Key Research
Peer-Reviewed Evidence • 1 Citations
NIA Interventions Testing Program: 17-α-Estradiol
••2016
Key Finding: 17-α-estradiol extended median lifespan by ~19% in male mice across 3 independent testing sites
Citations sourced from PubMed, Cochrane Library, and peer-reviewed journals. Study findings are summarized for accessibility. Always consult the original publication for full methodology and results.
📋 Protocol Snapshot
Protocols are for informational purposes only. Always consult a qualified healthcare provider before starting any treatment protocol.
Cost Guide
Research chemical pricing varies
Estimated UAE pricing. Costs vary by provider, dosage, and treatment plan.
Where to Get It (UAE)
Related Treatments
Medical Disclaimer: The information on this page is for educational purposes only and is not intended as medical advice. Kamura Scores reflect a combination of research evidence, community data, and other factors — they are not clinical recommendations. Research citations are provided for reference; always consult the original publications for complete study details. Consult a qualified healthcare provider before starting, stopping, or modifying any treatment. Individual results may vary.