17-α-Estradiol
17-Alpha-Estradiol (Non-Feminizing Estrogen)
Non-feminizing form of estradiol that has extended lifespan in male mice by ~19% in the NIA Interventions Testing Program. Unlike 17-β-estradiol, it does not cause feminizing effects. Mechanism involves metabolic improvements and mTOR pathway modulation.
📊 Evidence by Outcome
Extended lifespan (mice)
3 studies • Consistency: Moderate • Effect: Moderate
Improved metabolic health
3 studies • Consistency: Moderate • Effect: Moderate
Reduced inflammation
3 studies • Consistency: Moderate • Effect: Moderate
Key Research
Peer-Reviewed Evidence • 1 Citations
NIA Interventions Testing Program: 17-α-Estradiol
••2016
Key Finding: 17-α-estradiol extended median lifespan by ~19% in male mice across 3 independent testing sites
Citations sourced from PubMed, Cochrane Library, and peer-reviewed journals. Study findings are summarized for accessibility. Always consult the original publication for full methodology and results.
📋 Protocol Snapshot
Protocols are for informational purposes only. Always consult a qualified healthcare provider before starting any treatment protocol.
Cost Guide
Research chemical pricing varies
Estimated UAE pricing. Costs vary by provider, dosage, and treatment plan.
Related Treatments
Medical Disclaimer: The information on this page is for educational purposes only and is not intended as medical advice. Kamura Scores reflect a combination of research evidence, safety, accessibility, and value — they are not clinical recommendations. Research citations are provided for reference; always consult the original publications for complete study details. Consult a qualified healthcare provider before starting, stopping, or modifying any treatment. Individual results may vary.