Longevity Pharmaceuticals
Pharmaceutical compounds studied for longevity and anti-aging effects. Includes rapamycin (mTOR inhibitor), metformin, and other geroprotective drugs with clinical research.
Metformin
Metformin Hydrochloride (Off-Label Longevity)
A first-line diabetes drug with 60+ years of clinical history, now emerging as the most evidence-backed pharmaceutical for anti-aging. The Bannister study showed metformin users outliving non-diabetic controls, and the TAME trial is the first FDA-approved trial targeting aging itself.
Rapamycin
Rapamycin (Sirolimus) for Longevity
An mTOR inhibitor originally used in organ transplant patients, now emerging as the most evidence-backed pharmacological longevity intervention. The landmark Harrison 2009 study showed lifespan extension in mice, and the PEARL trial (2025) confirmed safety in healthy adults at longevity doses.