Low-Dose Naltrexone
Low-Dose Naltrexone (LDN)
An opioid antagonist used at ultra-low doses (1-4.5mg vs standard 50mg) to modulate the immune system and reduce chronic inflammation. Widely adopted in functional medicine for autoimmune conditions, chronic pain, and inflammatory disorders.
How Low-Dose Naltrexone Works
At low doses, naltrexone transiently blocks opioid receptors, causing a compensatory upregulation of endorphins and enkephalins. This modulates toll-like receptor 4 (TLR4) on microglia and immune cells, reducing neuroinflammation and systemic inflammatory cytokines.
📊 Evidence by Outcome
Benefits reported across multiple autoimmune conditions: MS, Crohn's, fibromyalgia, Hashimoto's. Mechanism involves transient endorphin elevation.
12 studies • Consistency: Moderate • Effect: Moderate
Reduced pain scores in fibromyalgia and chronic pain syndromes. May modulate microglial inflammation in the CNS.
8 studies • Consistency: Moderate • Effect: Moderate
Key Research
Peer-Reviewed Evidence • 1 Citations
Low-dose naltrexone for the treatment of fibromyalgia
Younger J et al.•Arthritis & Rheumatism•2013•PMID: 23553768
Key Finding: LDN (4.5mg/day) reduced fibromyalgia pain by 28.8% compared to placebo, with improvements in overall quality of life and mood.
View on PubMedCitations sourced from PubMed, Cochrane Library, and peer-reviewed journals. Study findings are summarized for accessibility. Always consult the original publication for full methodology and results.
📋 Protocol Snapshot
Protocols are for informational purposes only. Always consult a qualified healthcare provider before starting any treatment protocol.
Cost Guide
AED 100-250/month (compounding pharmacy)
Estimated UAE pricing. Costs vary by provider, dosage, and treatment plan.
Where to Get It (UAE)
Related Treatments
Medical Disclaimer: The information on this page is for educational purposes only and is not intended as medical advice. Kamura Scores reflect a combination of research evidence, community data, and other factors — they are not clinical recommendations. Research citations are provided for reference; always consult the original publications for complete study details. Consult a qualified healthcare provider before starting, stopping, or modifying any treatment. Individual results may vary.