MOTS-c
Mitochondrial Open Reading Frame of the 12S rRNA-c
A mitochondrial-derived peptide that enhances metabolic function, improves insulin sensitivity, and promotes exercise-like benefits at the cellular level.
Key Research
Peer-Reviewed Evidence • 3 Citations
MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis
Reynolds JC et al.•Nat Commun•2021•PMID: 34531413
Key Finding: MOTS-c treatment in aged mice improved physical performance comparable to exercise, regulating skeletal muscle gene expression.
View on PubMedThe mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance
Lee C et al.•Cell Metab•2015•PMID: 25738459
Key Finding: MOTS-c regulates metabolic homeostasis by targeting the methionine-folate cycle, preventing obesity and insulin resistance in mice.
View on PubMedMitochondrial-derived peptides in aging and age-related diseases
Kim SJ et al.•J Biomed Sci•2017•PMID: 28245826
Key Finding: MOTS-c represents a new class of mitochondrial signaling peptides that regulate metabolism and may slow age-related metabolic decline.
View on PubMedCitations sourced from PubMed, Cochrane Library, and peer-reviewed journals. Study findings are summarized for accessibility. Always consult the original publication for full methodology and results.
📊 Evidence by Outcome
Activates AMPK pathway, improves glucose metabolism. Animal data strong, human data emerging.
10 studies • Consistency: Moderate • Effect: Moderate
Mimics some benefits of exercise at the cellular level. Early-stage research.
5 studies • Consistency: Mixed • Effect: Unclear
👥 Community Insights
Energy levels noticeably improved. Feels like a metabolic boost.
Community member • Dubai• Verified
📋 Protocol Snapshot
Protocols are for informational purposes only. Always consult a qualified healthcare provider before starting any treatment protocol.
Where to Get It (UAE)
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Medical Disclaimer: The information on this page is for educational purposes only and is not intended as medical advice. Kamura Scores reflect a combination of research evidence, community data, and other factors — they are not clinical recommendations. Research citations are provided for reference; always consult the original publications for complete study details. Consult a qualified healthcare provider before starting, stopping, or modifying any treatment. Individual results may vary.