TB-500
Thymosin Beta-4
A naturally occurring peptide involved in tissue repair, wound healing, and recovery. Often stacked with BPC-157 for the 'Wolverine Protocol' — a popular post-surgery recovery combination.
How TB-500 Works
TB-500 is a synthetic version of the naturally occurring 43-amino-acid peptide Thymosin Beta-4, which is found in high concentrations in wound fluid and blood platelets. It works by upregulating actin, a cell-building protein essential for cell migration and proliferation at injury sites. TB-500 promotes angiogenesis, reduces inflammation by downregulating inflammatory cytokines, and supports stem cell maturation. Its systemic action means it does not need to be injected at the injury site to be effective.
📊 Evidence by Outcome
Strong preclinical evidence for accelerating tissue healing across multiple tissue types.
18 studies • Consistency: High • Effect: Large
Promotes angiogenesis and cell migration to injury sites. Human data limited but animal data robust.
12 studies • Consistency: High • Effect: Moderate
Some reports of hair regrowth as a secondary effect. Mechanism unclear.
3 studies • Consistency: Low • Effect: Small
Key Research
Peer-Reviewed Evidence • 3 Citations
Thymosin beta 4 promotes angiogenesis, wound healing, and hair growth
Philp D et al.•Ann N Y Acad Sci•2007•PMID: 17513460
Key Finding: TB-500 (thymosin beta-4) accelerates wound healing through promotion of cell migration, angiogenesis, and reduction of inflammation.
View on PubMedThymosin beta-4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair
Bock-Marquette I et al.•Nature•2004•PMID: 15229615
Key Finding: TB-500 protects cardiac cells after ischemic injury and promotes repair through ILK activation and Akt survival pathways.
View on PubMedThymosin beta 4: A multi-functional regenerative peptide
Goldstein AL et al.•Expert Opin Biol Ther•2012•PMID: 22171665
Key Finding: TB-500 demonstrates regenerative capacity across corneal, cardiac, and dermal tissue models with excellent safety profiles.
View on PubMedCitations sourced from PubMed, Cochrane Library, and peer-reviewed journals. Study findings are summarized for accessibility. Always consult the original publication for full methodology and results.
Side Effects & Safety
Interactions & Contraindications
Drug Interactions
- •May interact with anticoagulants (promotes blood vessel formation and modulates platelet function)
- •Theoretical interaction with immunosuppressants (modulates immune cell migration)
- •No well-documented pharmaceutical interactions
Supplement Interactions
- •Synergistic with BPC-157 for tissue healing (most popular peptide stack)
- •Compatible with collagen and glucosamine for joint support
- •May complement creatine for athletic recovery
Food & Timing
- •Can be taken with or without food (injectable form bypasses GI tract)
- •No known food interactions
- •Stay well hydrated during use
Who Should Avoid
- •Active cancer or history of cancer (promotes angiogenesis and cell migration)
- •Pregnancy and breastfeeding (insufficient safety data)
- •Children under 18
- •Recent head injury with active bleeding (promotes blood vessel growth)
📋 Protocol Snapshot
Protocols are for informational purposes only. Always consult a qualified healthcare provider before starting any treatment protocol.
Cost Guide
AED 500-1,500/month
Estimated UAE pricing. Costs vary by provider, dosage, and treatment plan.
Frequently Asked Questions
TB-500 is available through wellness clinics and peptide providers in the UAE. It is not a controlled substance but is also not an approved pharmaceutical. Source from reputable, licensed clinics only.
Most users notice reduced inflammation and pain improvement within 1-2 weeks. Full tissue repair and recovery benefits develop over 4-8 weeks. A loading phase (higher dose for 2-4 weeks) followed by maintenance dosing is the standard approach.
Yes, this is one of the most well-regarded peptide stacks. BPC-157 works locally at the injury site, while TB-500 provides systemic healing. Together they address both localized tissue repair and whole-body recovery, with many users reporting faster results than either peptide alone.
No. Unlike BPC-157, TB-500 is systemically active regardless of injection site. Subcutaneous injection in the abdomen or thigh is the most common method. The peptide travels through the bloodstream to reach injury sites throughout the body.
Where to Get It (UAE)
Related Treatments
Medical Disclaimer: The information on this page is for educational purposes only and is not intended as medical advice. Kamura Scores reflect a combination of research evidence, safety, accessibility, and value — they are not clinical recommendations. Research citations are provided for reference; always consult the original publications for complete study details. Consult a qualified healthcare provider before starting, stopping, or modifying any treatment. Individual results may vary.